Corona

UKE to start tests of corona vaccine in mid-October

6 October 2020
Initial vaccinations to be followed by second test phase possibly from late 2020

Scientists all over the globe are racing to come up with a vaccine to fight the novel coronavirus. The first 30 test persons in Hamburg will likely be vaccinated in mid-October, according to the University Hospital Hamburg-Eppendorf (UKE). This comes after the Paul-Ehrlich-Institut, the German federal institute for vaccines and biomedicines, approved clinical trials of the MVA-SARS-2-S vaccine. During the first phase, the vaccine will be tested for its safety, tolerability and immune response to the pathogen. The so-called vector vaccine has been developed by the German Centre for Infection Research (DZIF) and IDT Biologika GmbH. The universities of Munich and Marburg and UKE are taking part in the project. Dr.  Marylyn Addo, Head of Infectiology at UK, will oversee clinical trials in Hamburg.

Milestone en route to effective vaccine

Katharina Fegebank, Senator for Science, Research, Equality, remarked: "This is a first milestone en route to an effective corona vaccine." Meanwhile, Addo noted: "We are pleased about the Paul-Ehrlich-Institute's approval. The vaccine was developed with our DZIF co-operation partners Prof. Dr. Gerd Sutter from the Ludwig-Maximilians-University Munich and Prof. Dr. Stephan Becker from the Philipps-University Marburg over the past months. We are now testing the vaccine for efficacy and safety."

First tests 

The vaccine is a so-called vector vaccine against the SARS-CoV-2 virus, in which the genetic information for a surface protein of the SARS-CoV-2 virus is incorporated into a modified and thus harmless smallpox virus (MVA). This viral vector cannot reproduce, but the inserted DNA sequence - the component of the corona virus - can simulate an infection and trigger the production of antibodies and T cells.

Test persons between 18 and 55 years

The study will start with preliminary investigations and the selection of healthy, voluntary test persons in early October. The first volunteer will receive a low dose of the vaccine in mid-October. For safety reasons, only one volunteer will be vaccinated at first and the next two 24 hours later. 

Marylyn Addo, Head of Infectiology at UKE

A total of 30 voluntary test persons will be vaccinated in eight groups and with two ascending doses. The participants will receive two vaccinations at four-week intervals and will be required to come for regular outpatient follow-up visit over the next six months to assess their tolerability of the vaccine, possible side effects and the immune response based on blood tests and interviews.

Second test phase in late 2020

Plans are being laid for a broader Phase II clinical trial from late 2020, depending on the results of the first test phase, Addo said. Then more groups of test persons including older people will be included. The university hospitals in Tübingen, Marburg and Munich and other institutions will be involved in Phase II trials.
rr/sb/pb

Sources and further information

Similar articles

UKE: Patient, 23, gets world's tiniest electric pacemaker

New treatment for cardiac dysrhythmia at Heart and Vascular Center

UKE study identifies Sars-Cov-2 pathogen as multi-organ virus

Novel coronavirus attacks lungs and other organs - explanation for spectrum of symptoms?

E-health start-up Sympatient tops growth ranking

Hamburg's Sympatient among Germany's fastest growing start-ups - five other Hanseatic start-ups in rank

Corona Support Programme: Senate notes positive interim results

Hamburg provides corona aid to the amount of around 4.5 billion euros. Further programmes being planned, including digital bonus
The Consent Management Platform (https://app.usercentrics.eu/) we use could not be loaded. This can happen if AdBlockers incorrectly block this URL. Some features such as maps, proximity search or forms, cannot be used this way. To use these features, please deactivate your AdBlocker or allow access to *.usercentrics.eu.